HMMR alleviates endoplasmic reticulum stress by promoting autophagolysosomal activity during endoplasmic reticulum stress-driven hepatocellular carcinoma progression.

Lin HeHao LiCan LiZe-Kun LiuMeng LuRen-Yu ZhangDong WuDing WeiJie ShaoMan LiuHao-Lin WeiCong ZhangZhe WangLing-Min KongZhi-Nan ChenHui-Jie Bian

Published in: Cancer communications (London, England) (2023)

This study identified the complicated role of HMMR in autophagy and ER stress, that HMMR controls the intensity of ER stress by regulating autophagy in HCC progression, which could be a novel explanation for HBV-related carcinogenesis.

Keyphrases

endoplasmic reticulum stress
induced apoptosis
hepatitis b virus
oxidative stress
signaling pathway