High glucose enhances lipopolysaccharide-induced inflammation in cultured BV2 microglial cell line.
Hao-Chang HungSheng-Feng TsaiShih-Ren SieYu-Min KuoPublished in: Immunity, inflammation and disease (2022)
High glucose aggravated LPS-induced inflammatory responses of microglia via enhancing the TLR4/p38 pathway and prolonging the activation of NF-κB/iNOS signaling. Controlling blood glucose levels is advised to manage neuroinflammation and related neurodegenerative diseases.