Improved effects of honokiol on temozolomide-induced autophagy and apoptosis of drug-sensitive and -tolerant glioma cells.

Chung-Ching ChioKung-Yen ChenCheng-Kuei ChangJian-Ying ChuangChih-Chung LiuShing-Hwa LiuRuei-Ming Chen

Published in: BMC cancer (2018)

Taken together, this study demonstrated the improved effects of honokiol with TMZ on autophagy and subsequent apoptosis of drug-sensitive and -tolerant glioma cells. Thus, honokiol has the potential to be a drug candidate for treating human gliomas.

Keyphrases

endoplasmic reticulum stress
cell death
oxidative stress
cell cycle arrest
drug induced
endothelial cells
diabetic rats
signaling pathway
adverse drug
high glucose
emergency department
climate change
human health