Microbial involvement in Alzheimer disease development and progression.
Hannah R BulgartEvan W NeczyporLoren E WoldAmy R MackosPublished in: Molecular neurodegeneration (2020)
Alzheimer disease (AD) is the most prominent form of dementia and the 5th leading cause of death in individuals over 65. AD is a complex disease stemming from genetic, environmental, and lifestyle factors. It is known that AD patients have increased levels of senile plaques, neurofibrillary tangles, and neuroinflammation; however, the mechanism(s) by which the plaques, tangles, and neuroinflammation manifest remain elusive. A recent hypothesis has emerged that resident bacterial populations contribute to the development and progression of AD by contributing to neuroinflammation, senile plaque formation, and potentially neurofibrillary tangle accumulation (Fig. 1). This review will highlight recent studies involved in elucidating microbial involvement in AD development and progression.
Keyphrases
- mild cognitive impairment
- cognitive impairment
- lipopolysaccharide induced
- traumatic brain injury
- end stage renal disease
- lps induced
- microbial community
- ejection fraction
- newly diagnosed
- chronic kidney disease
- type diabetes
- prognostic factors
- weight loss
- patient safety
- gene expression
- peritoneal dialysis
- physical activity
- dna methylation
- quality improvement
- risk assessment
- human health
- subarachnoid hemorrhage