The -938C>A Polymorphism in MYD88 Is Associated with Susceptibility to Tuberculosis: A Pilot Study.
Kalliopi AggelouElena Konstantina SiapatiIrini GerogianniZoe DaniilKonstantinos GourgoulianisIoannis NtanosEmmanouel SimantirakisElias ZintzarasVassiliki MollakiGeorge VassilopoulosPublished in: Disease markers (2016)
Introduction. Tuberculosis (TB) is a major disease worldwide, caused by Mycobacterium tuberculosis (MTB) infection. The Toll-Like Receptor (TLR) pathway plays a crucial role in the recognition of MTB. Aim. The present study aimed to investigate the involvement of myeloid differentiation primary response protein 88 (MYD88) gene polymorphisms in TB. Materials and Methods. A total of 103 TB cases and 92 control subjects were genotyped for the MYD88 -938C>A (rs4988453) and 1944C>G (rs4988457) polymorphisms. Results. The MYD88 -938CA and -938AA genotypes were associated with an increased risk for tuberculosis with odds ratio (OR) of 5.71 (95% confidence intervals [CIs] 2.89-11.28, p = 0.01). Conclusions. The MYD88 -938C>A genetic polymorphism is associated with increased susceptibility to TB and may serve as a marker to screen individuals who are at risk.
Keyphrases
- mycobacterium tuberculosis
- toll like receptor
- pulmonary tuberculosis
- nuclear factor
- inflammatory response
- immune response
- acute myeloid leukemia
- dendritic cells
- genome wide
- high throughput
- dna methylation
- gene expression
- small molecule
- hiv infected
- amino acid
- copy number
- human immunodeficiency virus
- protein protein
- antiretroviral therapy
- hiv aids