Hydroalkylation of Olefins To Form Quaternary Carbons.

Samantha A GreenTucker R HuffmanRuairí O McCourtVincent A van der Puyl Lovett Ryan A Shenvi

Published in: Journal of the American Chemical Society (2019)

Metal-hydride hydrogen atom transfer (MHAT) functionalizes alkenes with predictable branched (Markovnikov) selectivity. The breadth of these transformations has been confined to π-radical traps; no sp3 electrophiles have been reported. Here we describe a Mn/Ni dual catalytic system that hydroalkylates unactivated olefins with unactivated alkyl halides, yielding aliphatic quaternary carbons.

Keyphrases

transition metal
metal organic framework
electron transfer
ionic liquid
visible light
molecular dynamics
room temperature