Prognostic impact of Notch1 receptor and clinicopathological High-Risk Predictors in lacrimal gland adenoid cystic carcinoma.
Shahzan AnjumSeema SenNeelam PushkerMandeep Singh BajajSeema KashyapSameer BakhshiKunzang ChosdolRachna MeelMehar Chand SharmaPublished in: Acta ophthalmologica (2021)
Our study demonstrates that overexpression of Notch1 receptor plays a critical role in the biology and aggressive behaviour of lacrimal gland ACC. Bone erosion, solid histologic pattern, advanced T stage, perineural invasion and intracranial extension are other high-risk clinicopathological predictors of lacrimal gland ACC.