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Association between INDELs in MicroRNAs and Susceptibility to Gastric Cancer in Amazonian Population.

Antônio André Conde ModestoMilene R de MoraesCristina M D ValenteMarta S C R CostaDiana Feio da Veiga Borges LealEsdras E B PereiraMarianne Rodrigues FernandesJhully A Dos S PinheiroKarla Beatriz Cardias Cereja PantojaFabiano Cordeiro MoreiraRommel Mario Rodríguez BurbanoPaulo P de AssumpçãoNey P C Dos SantosSidney Emanuel Batista Dos Santos
Published in: Genes (2022)
Gastric cancer (GC) is a multifactorial, complex, and aggressive disease with a prevalence of one million new cases and high global mortality. Factors such as genetic, epigenetic, and environmental changes contribute to the onset and progression of the disease. Identification of INDELs in miRNA and its target sites in current studies showed an important role in the development of cancer. In GC, miRNAs act as oncogenes or tumor suppressors, favoring important cancer pathways, such as cell proliferation and migration. This work aims to investigate INDELs in the coding region of miRNAs (hsa-miR-302c, hsa-miR-548AJ-2, hsa-miR-4274, hsa-miR-630, hsa-miR-516B-2, hsa-miR-4463, hsa-miR-3945, hsa-miR-548H_4, hsa-miR-920, has-mir-3171, and hsa-miR-3652) that may be associated with susceptibility and clinical variants of gastric cancer. For this study, 301 patients with GC and 145 individuals from the control group were selected from an admixed population in the Brazilian Amazon. The results showed the hsa-miR-4463, hsa-miR-3945, hsa-miR-548H_4, hsa-miR-920 and hsa-miR-3652 variants were associated with gastric cancer susceptibility. The hsa-miR-4463 was significantly associated with clinical features of GC such as diffuse gastric tumor histological type, "non-cardia" localization region, and early onset. Our findings indicated that INDELs could be potentially functional genetic variants for gastric cancer risk.
Keyphrases
  • cell proliferation
  • long non coding rna
  • long noncoding rna
  • early onset
  • cardiovascular disease
  • coronary artery disease
  • gene expression
  • mass spectrometry
  • climate change
  • low grade
  • papillary thyroid