Characterization of mismatch-repair (MMR)/microsatellite instability (MSI)-discordant endometrial cancers.
Courtney J RiedingerAshwini EsnakulaPaulina J HaightAdrian A SuarezWei ChenJessica GillespieAlyssa VillacresAlexis ChassenDavid E CohnPaul J GoodfellowCasey M CosgrovePublished in: Cancer (2023)
Endometrial cancer is the most common gynecologic cancer, and 20%-40% of tumors have a defect in DNA proofreading known as mismatch-repair (MMR) deficiency. These results can be used to guide therapy. Tests for this defect can yield differing results, revealing heterogeneous (mixed) proofreading capabilities. Tumors with discordant testing results and mixed MMR findings can have germline or somatic defects in MMR genes. Cells with deficient DNA proofreading in tumors with mixed MMR findings have DNA expression profiles linked to more aggressive characteristics and cancer spread. These MMR-deficient cells may drive tumor behavior and the risk of spreading cancer.
Keyphrases
- endometrial cancer
- papillary thyroid
- induced apoptosis
- circulating tumor
- squamous cell
- cell free
- single molecule
- cell cycle arrest
- stem cells
- lymph node metastasis
- childhood cancer
- squamous cell carcinoma
- oxidative stress
- cell death
- young adults
- dna methylation
- signaling pathway
- mesenchymal stem cells
- transcription factor
- cell proliferation
- cell therapy
- circulating tumor cells