Performance assessment and economic analysis of a human Liver-Chip for predictive toxicology.
Lorna EwartAthanasia ApostolouSkyler A BriggsChristopher V CarmanJake T ChaffAnthony R HengSushma JadalannagariJeshina JanardhananKyung-Jin JangSannidhi R JoshipuraMahika M KadamMarianne KanelliasVille J KujalaGauri KulkarniChristopher Y LeCarolina LucchesiDimitris V ManatakisKairav K ManiarMeaghan E QuinnJoseph S RavanAnn Catherine RizosJohn F K SauldJosiah D SlizWilliam Tien-StreetDennis Ramos TrinidadJames VelezMax WendellOnyi IrrechukwuPrathap Kumar MahalingaiahDonald E IngberJack W ScannellDaniel LevnerPublished in: Communications medicine (2022)
The results of this study show how incorporating predictive Organ-Chips into drug development workflows could substantially improve drug discovery and development, allowing manufacturers to bring safer, more effective medicines to market in less time and at lower costs.