Combination of talazoparib and olaparib enhanced the curcumin-mediated apoptosis in oral cancer cells by PARP-1 trapping.

Subhajit ChatterjeeAjit Kumar DhalSubarno PaulSaptarshi SinhaBiswajit DasSomya Ranjan DashChanakya Nath Kundu

Published in: Journal of cancer research and clinical oncology (2022)

Thus, induction of DNA damage was found to be essential for optimal functioning of PARPi and BMN + Ola combination treatment enhanced the apoptotic potentiality of Cur in cancer cells by enhancing the PARP-trapping activity via modulation of BER cascade.

Keyphrases

dna damage
dna repair
oxidative stress
combination therapy
anti inflammatory