Full-course NIR-II imaging-navigated fractionated photodynamic therapy of bladder tumours with X-ray-activated nanotransducers.
Liangrui HeLiyang WangXujiang YuYizhang TangZhao JiangGuoliang YangZhuang LiuWanwan LiPublished in: Nature communications (2024)
The poor 5-year survival rate for bladder cancers is associated with the lack of efficient diagnostic and treatment techniques. Despite cystoscopy-assisted photomedicine and external radiation being promising modalities to supplement or replace surgery, they remain invasive or fail to provide real-time navigation. Here, we report non-invasive fractionated photodynamic therapy of bladder cancer with full-course real-time near-infrared-II imaging based on engineered X-ray-activated nanotransducers that contain lanthanide-doped nanoscintillators with concurrent emissions in visible and the second near-infrared regions and conjugated photosensitizers. Following intravesical instillation in mice with carcinogen-induced autochthonous bladder tumours, tumour-homing peptide-labelled nanotransducers realize enhanced tumour regression, robust recurrence inhibition, improved survival rates, and restored immune homeostasis under X-ray irradiation with accompanied near-infrared-II imaging. On-demand fractionated photodynamic therapy with customized doses is further achieved based on quantifiable near-infrared-II imaging signal-to-background ratios. Our study presents a promising non-invasive strategy to confront the current bladder cancer dilemma from diagnosis to treatment and prognosis.
Keyphrases
- photodynamic therapy
- high resolution
- fluorescence imaging
- spinal cord injury
- magnetic resonance imaging
- type diabetes
- free survival
- squamous cell carcinoma
- adipose tissue
- magnetic resonance
- dual energy
- mass spectrometry
- small cell lung cancer
- minimally invasive
- quantum dots
- drug induced
- single molecule
- highly efficient
- locally advanced
- municipal solid waste