A Naïve Phage Display Library-Derived Nanobody Neutralizes SARS-CoV-2 and Three Variants of Concern.

Dandan WuJunxiao CongJiali WeiJing HuWenhao SunWei RanChenghui LiaoHousheng ZhengLiang Ye

Published in: International journal of nanomedicine (2023)

Our study highlights a novel nanobody, Nb-H6, that may be useful therapeutically in SARS-CoV-2 and VOC outbreaks and pandemics. These findings also provide a molecular foundation for further studies into how nanobodies neutralize SARS-CoV-2 and variants and imply potential therapeutic targets for the treatment of COVID-19.

Keyphrases

sars cov
respiratory syndrome coronavirus
copy number
pseudomonas aeruginosa
coronavirus disease
gene expression
cystic fibrosis
single molecule
human health
smoking cessation