A recombinant Bifidobacterium bifidum BGN4 strain expressing the streptococcal superoxide dismutase gene ameliorates inflammatory bowel disease.

Sini KangZhaoyan LinYang XuMinju ParkGeun Eog JiTony V JohnstonSeockmo KuMyeong Soo Park

Published in: Microbial cell factories (2022)

These findings suggest that B. bifidum BGN4-SK ameliorated DSS-induced colitis by generating antioxidant enzymes, maintaining the epithelial barrier, and decreasing the production of pro-inflammatory cytokines. Although B. bifidum BGN4-pBESIL10 exerted anti-inflammatory effects in vitro, the enhancement of IL-10 production and alleviation of colitis were very limited.

Keyphrases

anti inflammatory
oxidative stress
ulcerative colitis
genome wide
copy number
mouse model
gene expression
nitric oxide
cell free
dna methylation