How Many Biochemistries Are Available To Build a Cell?

Carlos G Acevedo-RochaDirk Schulze-Makuch

Published in: Chembiochem : a European journal of chemical biology (2015)

The manual experimental evolution of the bacterium Escherichia coli allowed the design of a noncanonical genetic code in which complete replacement of the endogenous building block tryptophan (left) by an exogenous one based on a thienylpyrrole (right) was achieved after 506 days of continuous culturing.

Keyphrases

escherichia coli
single cell
cell therapy
genome wide
gene expression
klebsiella pneumoniae
pseudomonas aeruginosa
bone marrow
cystic fibrosis