HIV-1 Tat phosphorylation on Ser-16 residue modulates HIV-1 transcription.

Andrey IvanovXionghao LinTatiana AmmosovaAndrey V IlatovskiyNamita KumariHatajai LassiterNowah AfangbedjiXiaomei NiuMichael G PetukhovSergei Nekhai

Published in: Retrovirology (2018)

Phosphorylation of Tat Ser-16 induces HIV-1 transcription, facilitates binding to TAR RNA and rearranges CDK9/cyclin T1/Tat complex. Thus, phosphorylation of Tat Ser-16 regulates HIV-1 transcription and may serve as target for HIV-1 therapeutics.

Keyphrases

antiretroviral therapy
hiv positive
hiv infected
hiv testing
human immunodeficiency virus
hepatitis c virus
hiv aids
men who have sex with men
south africa
cell cycle
small molecule
signaling pathway
cell death
cell proliferation
pi k akt
cell cycle arrest