Melatonin secretion following brain midline irradiation is diminished, but not correlated with subjective sleep disturbances.
Esther RosenkranzAndrea ThissenSonja SiegelMarc PirothHans ClusmannJudith GebauerGeorg BrabantIlonka Kreitschmann-AndermahrPublished in: Clinical endocrinology (2018)
Our data suggest that radiation exposure to the pineal gland negatively affects melatonin secretion. This lack of pineal melatonin does not influence subjective sleep quality. As melatonin has important antioxidant and cancer-protective effects, further research is necessary to elucidate whether these patients have an increased risk of developing secondary neoplasms and other radiation late effects.
Keyphrases
- childhood cancer
- sleep quality
- depressive symptoms
- end stage renal disease
- physical activity
- ejection fraction
- newly diagnosed
- chronic kidney disease
- radiation induced
- oxidative stress
- electronic health record
- machine learning
- big data
- squamous cell carcinoma
- patient reported outcomes
- radiation therapy
- multiple sclerosis
- deep learning
- artificial intelligence
- blood brain barrier
- papillary thyroid
- cerebral ischemia