The Role of Myeloid-Derived Suppressor Cells (MDSCs) in Graft-versus-Host Disease (GVHD).

Christos DemosthenousIoanna SakellariVassiliki DoukaPenelope Georgia Papayanni Achilles Anagnostopoulos Eugenia Gkaliagkousi

Published in: Journal of clinical medicine (2021)

The induction or maintenance of MDSC suppressive function would be advantageous in suppressing inflammation associated with GVHD. Pathways involved in MDSC metabolism and the inflammasome signaling are a promising field of study to elucidate the function of MDSCs in the pathogenesis of GVHD and translate these findings to a clinical setting.

Keyphrases

allogeneic hematopoietic stem cell transplantation
induced apoptosis
oxidative stress
signaling pathway
cell cycle arrest
acute lymphoblastic leukemia
acute myeloid leukemia
cell death
cell proliferation