Mitochondrial haplogroups have a better correlation to insulin requirement than nuclear genetic variants for type 2 diabetes mellitus in Taiwanese individuals.

Feng-Chih ShenShao-Wen WengMeng-Han TsaiYu-Jih SuSung-Chou LiShun-Jen ChangJung-Fu ChenYen-Hsiang ChangChia-Wei LiouTsu-Kung LinJiin-Haur ChuangChing-Yi LinPei-Wen Wang

Published in: Journal of diabetes investigation (2021)

Mitochondrial haplogroups, but not nuclear genetic variants, have a better association with the insulin requirement. The results highlight the role of mitochondria in the management of common metabolic diseases.

Keyphrases

glycemic control
type diabetes
oxidative stress
cell death
adipose tissue
skeletal muscle