Arabidopsis thaliana alternative dehydrogenases: a potential therapy for mitochondrial complex I deficiency? Perspectives and pitfalls.

Alessia CataniaArcangela IusoJuliette BouchereauLaura S KremerMarina PavioloCaterina TerrilePaule BénitAllan G RasmussonThomas SchwarzmayrValeria TirantiPierre RustinMalgorzata RakHolger ProkischManuel Schiff

Published in: Orphanet journal of rare diseases (2019)

In conclusion, despite their promising potential to rescue CI defects, due to a possible competition with remaining CI activity, plant NDH-2 should be regarded with caution as potential therapeutic tools for human mitochondrial diseases.

Keyphrases

arabidopsis thaliana
oxidative stress
endothelial cells
human health
risk assessment