Human parietal epithelial cells (PECs) and proteinuria in lupus nephritis: a role for ClC-5, megalin, and cubilin?

Monica CeolLisa GianeselloHernan TrimarchiAlberto MiglioriniGiovanna PrianteClaudia M RaduElena NasoAnnalisa AngeliniLorenzo A CalòFranca AnglaniDorella Del Prete

Published in: Journal of nephrology (2023)

Our results may provide further insight into the role of hypertrophic parietal epithelial cells located at the tubular pole and their possible involvement in protein endocytosis in lupus nephritis patients. These data also suggest that the presence of hypertrophic parietal epithelial cells in Bowman's capsule represents a potential resource for responding to protein overload observed in other glomerulonephritis.

Keyphrases

working memory
end stage renal disease
endothelial cells
newly diagnosed
ejection fraction
protein protein
prognostic factors
peritoneal dialysis
amino acid
binding protein
machine learning
electronic health record
big data
risk assessment
climate change
patient reported outcomes
patient reported
data analysis