Genomic Predictors of Recurrence Patterns After Complete Resection of Colorectal Liver Metastases and Adjuvant Hepatic Artery Infusion Chemotherapy.

Raja R NarayanJashodeep DattaDebra A GoldmanVictoria G AvesonHenry S WalchFrancisco Sanchez-VegaMithat GönenVinod P BalachandranJeffrey A DrebinWilliam R JarnaginT Peter KinghamAlice C WeiNikolaus SchultzNancy E KemenyMichael I D'Angelica

Published in: Annals of surgical oncology (2022)

Altered KRAS, RAS/RAF, and RAS/RAF-TP53 associated with earlier local and distant recurrence in resected CRLM patients receiving adjuvant HAI+SYS. Co-altered RAS/RAF-TP53 was a novel predictor of LR warranting investigation of whether genomic cooperativity is associated with this relapsing phenotype. Systemic therapies tailored to high-risk tumor biology are needed to reduce distant relapse after hepatectomy.

Keyphrases

liver metastases
wild type
free survival
lymph node
early stage
multiple sclerosis
copy number
low dose
radiation therapy
smoking cessation