Linezolid-induced thrombocytopenia increases mortality risk in intensive care unit patients, a 10 year retrospective study.
Hyung-Sook KimEunsook LeeYoung-Jae ChoYeon Joo LeeSandy Jeong Yeon RhiePublished in: Journal of clinical pharmacy and therapeutics (2018)
Critically ill patients with any malignancy or an elevated baseline creatinine level who were treated with linezolid in the ICU were more likely to develop thrombocytopenia. More importantly, mortality increased with patients who developed linezolid-induced thrombocytopenia compared to those did not.
Keyphrases
- intensive care unit
- high glucose
- methicillin resistant staphylococcus aureus
- newly diagnosed
- diabetic rats
- end stage renal disease
- ejection fraction
- mechanical ventilation
- drug induced
- type diabetes
- prognostic factors
- cardiovascular events
- endothelial cells
- risk factors
- staphylococcus aureus
- metabolic syndrome
- patient reported outcomes
- acute respiratory distress syndrome