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Safety evaluation of pembrolizumab for treating recurrent head and neck squamous cell carcinoma.

Antoine DesiletsDenis Soulières
Published in: Expert opinion on drug safety (2020)
Superior OS for pembrolizumab as first-line monotherapy was demonstrated in the CPS ≥ 20 and CPS ≥ 1 populations, with favorable toxicity profile when compared to the EXTREME regimen. Patient selection through adequate PD-L1 scoring is thus essential in order to limit upfront exposure to combination chemotherapy. Further trials are currently investigating the safety of PD-L1 inhibitors, alone or in combination with anti-CTLA-4 therapies.
Keyphrases
  • advanced non small cell lung cancer
  • oxidative stress
  • climate change
  • squamous cell carcinoma
  • clinical trial
  • epidermal growth factor receptor
  • oxide nanoparticles