Cantharidin overcomes IL-2Rα signaling-mediated vorinostat resistance in cutaneous T-cell lymphoma through reactive oxygen species.

Man ZhuWenjun TangXiaoyu TangZeren ZhuYina JiangAmmar SarwarHongmei ZhangDake ChuZixi ZhangYanmin Zhang

Published in: Journal for immunotherapy of cancer (2024)

Our study uncovers a novel molecular mechanism of acquired SAHA resistance and also suggests that using cantharidin is a potential approach to overcome CTCL therapy resistance. Our findings underlie the therapeutic potential of cantharidin in treating CTCL.

Keyphrases

reactive oxygen species
histone deacetylase
stem cells
bone marrow
climate change