Role of transforming growth factor-β1 pathway in angiogenesis induced by chronic stress in colorectal cancer.

Jie ZhangYao-Tiao DengJie LiuLu GanYu Jiang

Published in: Cancer biology & therapy (2024)

Our results demonstrate the effect of NE on tumor angiogenesis and the critical role of TGF-β1 signaling during this process. In addition, β-AR/TGF-β1 signaling/HIF-1α/VEGF is a potential signaling pathway. This study also indicates that psychosocial stress might be a risk factor which weakens the efficacy of anti-angiogenic therapy.

Keyphrases

transforming growth factor
epithelial mesenchymal transition
endothelial cells
vascular endothelial growth factor
signaling pathway
risk factors
mental health
wound healing
stem cells
risk assessment
mesenchymal stem cells
cell therapy