Suppression of AMP-activated protein kinase reverses osteoprotegerin-induced inhibition of osteoclast differentiation by reducing autophagy.

Xishuai TongChuang ZhangDong WangRuilong SongYonggang MaYing CaoHongyan ZhaoJianchun BianJianhong GuZongping Liu

Published in: Cell proliferation (2019)

These results demonstrated that the AMPK signalling pathway functions as a critical regulator in the OPG-mediated inhibition of OC differentiation, by inducing autophagy. Our results provide a basis for future bone-related studies on the AMPK signalling pathway.

Keyphrases

protein kinase
cell death
endoplasmic reticulum stress
oxidative stress
signaling pathway
bone loss
diabetic rats
high glucose
bone mineral density
current status
drug induced
transcription factor
nuclear factor
inflammatory response
endothelial cells