Homalolides C-D, two new sesquiterpenoids from the rhizomes of Homalomena pendula .

Two new sesquiterpenoids, homalolides C - D (1 ‒ 2) , were co-isolated from the rhizomes of Homalomena pendula (Blume) Bakh.f collected in Vietnam with five known ones, aromadendrane-4 α ,10 α -diol ( 3 ), bullatantriol ( 4 ), 1 β ,4 β ,6 α -trihydroxy-eudesmane ( 5 ), 1 β ,4 β ,6 β -trihydroxyeudesmane ( 6 ), and 1 β ,4 β ,7 α -trihydroxy-eudesmane ( 7 ). The structures and relative configuration of new compounds were elucidated by 1 D-/2D-NMR, IR, UV and HRESIMS analyses, and by comparisons to the reported data in the literature. Homalolide C presented an unprecedented skeleton with the 4/8 bicyclic system. All isolates did not exhibit appreciable inhibitory effects on LPS-induced NO production in the RAW 264.7 macrophage cell line and on the growth of human lung cancer cell line (SK-LU-1).