KPI-121 1% for pain and inflammation in ocular surgery.
Kenneth A BeckmanJames A KatzParag A MajmudarAaron Gabriel RipsNeel S VaidyaAudrey Talley RostovPublished in: Pain management (2021)
Pain and inflammation are common experiences following ocular surgery and, if uncontrolled, can compromise patients' vision, functioning and quality of life. Corticosteroid drugs are available to manage inflammation and discomfort but have limitations in penetrating the ocular mucus barrier to reach the target ocular tissues. KPI-121 1% (INVELTYS®) is a novel formulation of loteprednol etabonate that employs innovative proprietary technology to deliver nanoparticle-sized mucus-penetrating particles to the cornea. Results from clinical trials demonstrate that KPI-121 1% is effective and well tolerated. KPI-121 1% uses mucopenetrative technology for ophthalmic use and is the only US FDA-approved twice-daily ocular corticosteroid indicated for the treatment of inflammation and pain after ocular surgery.
Keyphrases
- oxidative stress
- minimally invasive
- chronic pain
- coronary artery bypass
- clinical trial
- optic nerve
- pain management
- neuropathic pain
- end stage renal disease
- gene expression
- ejection fraction
- coronary artery disease
- prognostic factors
- peritoneal dialysis
- drug delivery
- spinal cord injury
- open label
- combination therapy
- patient reported
- study protocol