Genetic portrait of 23 Y-STR loci in the Naga tribes of Nagaland, India.
Bhawana JoshiSentibenla LemturMarlyn HumtsoeKapil VermaR K KumawatPushpesh KushwahaAkshay KumarKunwar Veer Vikram SrivastavAnkit SrivastavaPankaj ShrivastavaPublished in: International journal of legal medicine (2021)
To explore the genomic diversity and forensic characterization of Naga tribes, Nagaland, haplotypes for 23 Y-STR markers have been analyzed. In this study, 203 unrelated male individuals residing in the Northeast Indian state of Nagaland were selected. A total of 203 unique haplotypes were observed. The value of gene diversity (GD) and discrimination capacity (DC) was observed as 0.999999998927955 and 1 respectively. Forensic interest parameters viz., power of discrimination (PD), polymorphic information content (PIC), and matching probability (PM) were found to be 0.999999998695503, 0.999999976671191, and 1.3 × 10-9 respectively, for the studied population. Inter-population comparison study showed that the Naga tribes were found to have a distinct gene pool which is reflected in the neighbor-joining tree, principle coordinate analysis, and heat map. This is the first genetic study on Naga tribes based on 23 Y-STR markers. The Y chromosomal STR data will be useful for forensic DNA application and will enrich the existing Indian Y-STR database.
Keyphrases
- copy number
- genome wide
- emergency department
- particulate matter
- healthcare
- gene expression
- air pollution
- electronic health record
- machine learning
- heavy metals
- transcription factor
- cell free
- circulating tumor
- social media
- risk assessment
- artificial intelligence
- genome wide identification
- circulating tumor cells
- data analysis