Advanced baseline immunosuppression is associated with elevated levels of plasma markers of fungal translocation and inflammation in long-term treated HIV-infected Tanzanians.
Godfrey BarabonaMacdonald MahitiMako ToyodaDoreen KamoriSalim MasoudGeorge P JudicateBruno SunguyaEligius LyamuyaTakamasa UenoPublished in: AIDS research and therapy (2021)
Our data suggest that advanced immunosuppression at ART initiation is associated with severity of inflammation and elevated fungal translocation marker despite long term virological control. Further studies are needed to evaluate the potential increased burden of non-AIDS comorbidities that are linked to elevated inflammatory and fungal translocation markers as a result of the policy of HIV treatment at CD4 count < 200 cells/cm3 implemented for over a decade in Tanzania.
Keyphrases
- hiv infected
- antiretroviral therapy
- oxidative stress
- human immunodeficiency virus
- hiv positive
- hiv infected patients
- hiv aids
- induced apoptosis
- healthcare
- public health
- cell cycle arrest
- cell wall
- electronic health record
- mental health
- machine learning
- risk factors
- south africa
- hepatitis c virus
- smoking cessation
- nk cells