Electrical conductance measurement of HgII-mediated DNA duplex in buffered aqueous solution.

Ryo YamadaIssei NomuraYuki YamaguchiYosuke MatsudaYoshikazu HattoriHirokazu TadaAkira OnoYoshiyuki Tanaka

Published in: Nucleosides, nucleotides & nucleic acids (2020)

Electrical properties of metal-mediated DNA duplexes (metallo-DNA) have been of particular interest because of their potential applications in DNA-based nanoelectronics. We prepared HgII-mediated DNA duplex with NH2 anchors and measured the electrical conductance of single-molecule metallo-DNA via scanning tunneling microscopy-based break junction method in the buffered solution. Three conductance values were observed that may correspond to different conformations of the metallo-DNA molecule bridged over metallic electrodes.

Keyphrases

single molecule
circulating tumor
cell free
living cells
atomic force microscopy
high resolution
risk assessment
circulating tumor cells
gram negative
multidrug resistant
optical coherence tomography