Resveratrol-nitric oxide donor hybrid effect on priapism in sickle cell and nitric oxide-deficient mouse.

Andressa Kely PinheiroDalila Andrade PereiraJean Leandro Dos SantosFabiano Beraldi CalmasiniEduardo Costa AlexandreLeonardo Oliveira ReisArthur L BurnettFernando Ferreira CostaFábio Henrique Silva

Published in: PloS one (2022)

Treatment with RVT-FxMe reversed the enhanced NO-cGMP-mediated CC relaxations in eNOS-/- mice, but not in SCD mice; it is likely that excess of plasma hemoglobin in SCD mice act to inactivate NO before it reaches soluble guanylyl cyclase, avoiding restoration of NO bioavailability in penis.

Keyphrases

nitric oxide
nitric oxide synthase
high fat diet induced
hydrogen peroxide
wild type
type diabetes
adipose tissue
smoking cessation