Methylome analyses of three glioblastoma cohorts reveal chemotherapy sensitivity markers within DDR genes.

Tobias KesslerAnne BerberichAhmed SadikFelix SahmThierry GorliaChristoph MeisnerDirk C HoffmannAntje WickPhilipp KickingerederPetra RübmannMartin BendszusChristiane OpitzMichael WellerMartin van den BentRoger StuppFrank WinklerAlba Ariela BrandesAndreas von DeimlingMichael Platten Wolfgang Wick

Published in: Cancer medicine (2020)

Hypomethylation of DDR genes and TERT promoter mutations is associated with worse tumor prognosis, dependent on the methylation cluster and MGMT promoter methylation status in IDH wild-type glioblastoma.

Keyphrases

genome wide
dna methylation
wild type
gene expression
transcription factor
locally advanced
squamous cell carcinoma
low grade
radiation therapy
genome wide analysis
rectal cancer