Login / Signup

Prolonged central apnoea after intravenous morphine administration in a 12-year-old male with a UGT1A1 loss-of-function polymorphism.

Michael S ToceHyun KimSarita ChungBaruch S Krauss
Published in: British journal of clinical pharmacology (2018)
When appropriate, physicians should enquire about prior receipt of opioids, in both the patient and family, to be better prepared for potential adverse reactions. In the patient with excessive sedation or respiratory depression to standard doses of morphine, genetic testing may be warranted, especially if there is a family or past history that supports a metabolic defect in morphine metabolism and/or excretion.
Keyphrases
  • case report
  • primary care
  • chronic pain
  • high dose
  • low dose
  • risk assessment
  • body mass index
  • climate change
  • acute respiratory distress syndrome
  • sleep apnea