Positive personality traits moderate persistent high alcohol consumption, determined by polygenic risk in U.S. military veterans: results from a 10-year, population-based, observational cohort study.

Peter J Na Hang Zhou Janitza L Montalvo-Ortiz Brenda Cabrera-Mendoza Ismene L Petrakis John H Krystal Renato Polimanti Joshua C Gray Robert H Pietrzak

Published in: Psychological medicine (2023)

AUDIT-C PRS was prospectively associated with persistent HAC over a 10-year period, and agreeableness and dispositional gratitude moderated this association. Clinical interventions designed to target these modifiable psychological traits may help mitigate risk of persistent HAC in veterans with greater polygenic liability for persistent HAC.

Keyphrases

alcohol consumption
physical activity
gene expression
high intensity
dna methylation
posttraumatic stress disorder