Potentiation of temozolomide activity against glioblastoma cells by aromatase inhibitor letrozole.
Aniruddha S KarveJanki M DesaiNimita DaveTrisha M Wise-DraperGary A GudelskyTimothy N PhoenixBiplab DasGuptaSoma SenguptaDavid R PlasPankaj B DesaiPublished in: Cancer chemotherapy and pharmacology (2022)
LTZ increases DNA damage and synergistically enhances TMZ activity in TMZ sensitive and TMZ-resistant GBM lines. These effects are abrogated by the addition of exogenous estradiol underscoring that the observed effects of LTZ may be mediated by estrogen deprivation. Our study provides a strong rationale for investigating the clinical potential of combining LTZ and TMZ for GBM therapy.