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Auger Electrons Constructed Active Sites on Nanocatalysts for Catalytic Internal Radiotherapy.

Weiwei SuHan WangTao WangXiao LiZhongmin TangShuai ZhaoMeng ZhangDanni LiXingwu JiangTeng GongWei YangChangjing ZuoYelin WuWen-Bo Bu
Published in: Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2020)
Excess electrons play important roles for the construction of superficial active sites on nanocatalysts. However, providing excess electrons to nanocatalysts in vivo is still a challenge, which limits the applications of nanocatalysts in biomedicine. Herein, auger electrons (AEs) emitted from radionuclide 125 (125I) are used in situ to construct active sites in a nanocatalyst (TiO2) and the application of this method is further extended to cancer catalytic internal radiotherapy (CIRT). The obtained 125I-TiO2 nanoparticles first construct superficial Ti3+ active sites via the reaction between Ti4+ and AEs. Then Ti3+ stretches and weakens the O-H bond of the absorbed H2O, thus enhancing the radiolysis of H2O molecules and generating hydroxyl radicals (•OH). All in vitro and in vivo results demonstrate a good CIRT performance. These findings will broaden the application of radionuclides and introduce new perspectives to nanomedicine.
Keyphrases
  • early stage
  • locally advanced
  • radiation therapy
  • quantum dots
  • papillary thyroid
  • wastewater treatment
  • squamous cell carcinoma
  • rectal cancer
  • visible light