Experimental colitis promotes sustained, sex-dependent, T-cell-associated neuroinflammation and parkinsonian neuropathology.
Madelyn C HouserW Michael CaudleJianjun ChangGeorge T KannarkatYuan YangSean D KellyDanielle OliverValerie JoersKathleen M ShannonAli KeshavarzianMalú Gámez TanseyPublished in: Acta neuropathologica communications (2021)
This study identifies peripheral inflammatory mechanisms in PD patients and explores their potential to impact central dopaminergic pathways in mice. Our findings implicate a sex-specific interaction between gastrointestinal inflammation and neurologic vulnerability that could contribute to PD pathogenesis, and they establish the importance of CD8+ T-cells in this process in male mice.
Keyphrases
- end stage renal disease
- oxidative stress
- ejection fraction
- chronic kidney disease
- newly diagnosed
- prognostic factors
- climate change
- traumatic brain injury
- peritoneal dialysis
- type diabetes
- lipopolysaccharide induced
- risk assessment
- inflammatory response
- high fat diet induced
- lps induced
- brain injury
- insulin resistance
- skeletal muscle
- patient reported