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Experimental colitis promotes sustained, sex-dependent, T-cell-associated neuroinflammation and parkinsonian neuropathology.

Madelyn C HouserW Michael CaudleJianjun ChangGeorge T KannarkatYuan YangSean D KellyDanielle OliverValerie JoersKathleen M ShannonAli KeshavarzianMalú Gámez Tansey
Published in: Acta neuropathologica communications (2021)
This study identifies peripheral inflammatory mechanisms in PD patients and explores their potential to impact central dopaminergic pathways in mice. Our findings implicate a sex-specific interaction between gastrointestinal inflammation and neurologic vulnerability that could contribute to PD pathogenesis, and they establish the importance of CD8+ T-cells in this process in male mice.
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