Eosinophilic meningoencephalitis caused by rat lungworm (Angiostrongylus cantonensis) migration in a white-eared opossum (Didelphis albiventris) with concurrent distemper virus in southern Brazil.
Andréia VielmoClaiton Ismael SchwertzManoela Marchezan PivaJoanna Vargas Zillig EcheniqueCíntia De LorenzoLívia Eichenberg SuritaCaroline Pinto de AndradeLuciana SonnePublished in: Parasitology research (2022)
Angiostrongylus cantonensis is a worldwide zoonotic parasite that causes eosinophilic meningoencephalitis in many species of animals including humans. This report describes neuro-angiostrongylosis in a white-eared opossum that showed nervous clinical signs such as circling and depression. At necropsy, no relevant macroscopic lesions were observed. Histologically, eosinophilic meningoencephalitis was associated with multiple sections of nematodes and many intracytoplasmic eosinophilic inclusion bodies within gastric parietal cells. Immunohistochemistry was strongly positive for canine distemper virus in the stomach but there was no immunolabeling in the brain. This study describes a fatal case of eosinophilic meningoencephalitis by A. cantonensis with canine distemper virus concurrent infection in a white-eared opossum in southern Brazil, with histological characterization and molecular confirmation of the parasitism.
Keyphrases
- chronic rhinosinusitis
- induced apoptosis
- locally advanced
- oxidative stress
- squamous cell carcinoma
- white matter
- working memory
- cell cycle arrest
- resting state
- multiple sclerosis
- cell proliferation
- sleep quality
- brain injury
- blood brain barrier
- cerebral ischemia
- plasmodium falciparum
- trypanosoma cruzi
- genetic diversity
- endoscopic submucosal dissection