BRMS1: a multifunctional signaling molecule in metastasis.
Rosalyn C ZimmermannDanny R WelchPublished in: Cancer metastasis reviews (2021)
Despite high mortality rates, molecular understanding of metastasis remains limited. It can be regulated by both pro- and anti-metastasis genes. The metastasis suppressor, breast cancer metastasis suppressor 1 (BRMS1), has been positively correlated with patient outcomes, but molecular functions are still being characterized. BRMS1 has been implicated in focal adhesion kinase (FAK), epidermal growth factor receptor (EGFR), and NF-κB signaling pathways. We review evidence that BRMS1 regulates these vast signaling pathways through chromatin remodeling as a member of mSin3 histone deacetylase complexes.
Keyphrases
- epidermal growth factor receptor
- signaling pathway
- tyrosine kinase
- histone deacetylase
- small cell lung cancer
- advanced non small cell lung cancer
- pi k akt
- gene expression
- genome wide
- drug delivery
- type diabetes
- dna damage
- oxidative stress
- transcription factor
- induced apoptosis
- cardiovascular events
- inflammatory response
- young adults
- cystic fibrosis
- endoplasmic reticulum stress