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Neonatal thrombocytopenia-causes and outcomes following platelet transfusions.

Elisabeth ReschOlesia HinkasBerndt UrlesbergerBernhard Resch
Published in: European journal of pediatrics (2018)
Prematurity and diagnoses including early and late onset sepsis and asphyxia were the most common causes of NT. Mortality was not associated with the severity of NT but increased with the number of PT. What is Known: • The causes for neonatal thrombocytopenia (NT) are well known. • The effects of platelet transfusions (PT) and its indications are still a matter of debate and recommendations differ widely. What is New: • The duration of NT is positively related to the severity of NT and the number of subsequent PT. • The mortality rate is not associated with the severity of NT but increases with increasing numbers of PT and in the case of relevant intraventricular hemorrhage (≥ grade II), PT does not influence the mortality rate.
Keyphrases
  • late onset
  • cardiovascular events
  • early onset
  • intensive care unit
  • preterm infants
  • acute kidney injury
  • coronary artery disease
  • clinical practice
  • low birth weight
  • septic shock