Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs.

Sang Jae LeeJang-Sik ChoiByeong-Gu HanHyoun Sook KimHo-Juhn SongJaekyoo LeeSeungyoon NamSung-Ho GohJung-Ho KimJong Sung KohByung Il Lee

Published in: The FEBS journal (2017)

The atomic coordinates and structure factors for human SYK are in the Protein Data Bank under accession codes 4XG2 (inhibitor-free form), 4XG3 (G206), 4XG4 (G207), 5GHV (O178), 4XG6 (O194), 4XG7 (O259), 4XG8 (O272), and 4XG9 (O282).

Keyphrases

tyrosine kinase
epidermal growth factor receptor
endothelial cells
machine learning
amino acid
deep learning
binding protein
artificial intelligence
induced pluripotent stem cells