Anti-Inflammatory Effects of Peripheral Dopamine.
Shaun C MoorePedro Alves Soares Vaz de CastroDaniel YaqubPedro A JoseInes ArmandoPublished in: International journal of molecular sciences (2023)
Dopamine is synthesized in the nervous system where it acts as a neurotransmitter. Dopamine is also synthesized in a number of peripheral organs as well as in several types of cells and has organ-specific functions and, as demonstrated more recently, is involved in the regulation of the immune response and inflammatory reaction. In particular, the renal dopaminergic system is very important in the regulation of sodium transport and blood pressure and is particularly sensitive to stimuli that cause oxidative stress and inflammation. This review is focused on how dopamine is synthesized in organs and tissues and the mechanisms by which dopamine and its receptors exert their effects on the inflammatory response.
Keyphrases
- oxidative stress
- uric acid
- inflammatory response
- blood pressure
- immune response
- induced apoptosis
- prefrontal cortex
- metabolic syndrome
- gene expression
- dna damage
- lipopolysaccharide induced
- ischemia reperfusion injury
- toll like receptor
- adipose tissue
- hypertensive patients
- cell cycle arrest
- cell death
- endoplasmic reticulum stress
- heat shock protein