Construction of immune/Creutzfeldt-Jakob disease-related gene coexpression network to predict biomarkers.

Xiaoou HaiJiaming ZhouGuangyan Liu

Published in: European journal of neurology (2021)

Our coexpression network analysis revealed a close connection between CJD- and immune-associated genes, and we identified six CJD-specific modules. Biological function analysis of CJD-specific module genes revealed that immune responses are associated with CJD pathophysiology and may provide novel diagnostic and therapeutic biomarkers for this disease.

Keyphrases

network analysis
genome wide
genome wide identification
immune response
single cell
genome wide analysis
bioinformatics analysis
copy number
dendritic cells
toll like receptor
gene expression
transcription factor