A novel rare CUBN variant and three additional genes identified in Europeans with and without diabetes: results from an exome-wide association study of albuminuria.
Tarunveer Singh AhluwaliaChristina-Alexandra SchulzJohannes WaageTea SkaabyNiina SandholmNatalie van ZuydamRomain CharmetJette Bork-JensenPeter AlmgrenBetina H ThuesenMathilda BedinIvan BrandslundCramer K ChristensenAllan LinnebergEmma AhlqvistPer-Henrik GroopSamy HadjadjDavid-Alexandre TregouetMarit E JørgensenNiels GrarupOluf PedersenMatias SimonsLeif GroopMarju Orho-MelanderMark I McCarthyOlle MelanderPeter RossingTuomas O KilpeläinenTorben HansenPublished in: Diabetologia (2018)
The current study identifies a rare coding variant in the CUBN locus and other potential genes associated with albuminuria in individuals with and without diabetes. These genes have been implicated in renal and cardiovascular dysfunction. The findings provide new insights into the genetic architecture of albuminuria and highlight target genes and pathways for the prevention of diabetes-related kidney disease.