Low ectonucleotidase activity and increased neutrophil-platelet aggregates in patients with antiphospholipid syndrome.
Somanathapura K NaveenKumarAjay TambralliBruna Mazetto FonsecaSrilakshmi YalavarthiWenying LiangClaire K HoyCyrus SaroshChristine E RysengaCaroline H RangerCaroline E VanceJacqueline A MadisonFernanda A OrsiSuman L SoodJordan K SchaeferYu ZuoChristian LoodPublished in: Blood (2024)
Many patients with antiphospholipid syndrome had decreased ectonucleotidase activity on neutrophils and platelets, which enabled extracellular nucleotides to trigger neutrophil-platelet aggregates. This phenotype was replicated by treating healthy neutrophils and platelets with patient-derived antiphospholipid antibodies or ectonucleotidase inhibitors.