Protein biomarkers and alternatively methylated cell-free DNA detect early stage pancreatic cancer.
Roni Ben AmiQiao-Li WangJinming ZhangJulianna G SuppleeJohannes F FahrmannRoni Lehmann-WermanLauren K BraisJonathan Andrew NowakChen YuanMaureen LoftusAna BabicEhsan IrajizadTal DavidiAviad ZickAyala HubertDaniel NeimanSheina PiyanzinOfer Gal-RosenbergAmit HornRuth ShemerBenjamin GlaserNatalia BoosKunal JajooLinda LeeThomas E ClancyDouglas A RubinsonKimmie NgJohn A ChabotFay KastrinosMichael KlugerAndrew J AguirrePasi A JänneNabeel BardeesyBen StangerMark H O'HaraJacob TillAnirban MaitraErica L CarpenterAndrea J BullockJeanine GenkingerSamir M HanashCloud P PaweletzYuval DorBrian M WolpinPublished in: Gut (2023)
A combined panel of circulating markers including proteins and methylated cfDNA increased discrimination compared with CA19-9 alone for early stage PDAC.