Intranasal galantamine/chitosan complex nanoparticles elicit neuroprotection potentials in rat brains via antioxidant effect.
Lamia Said KandilRagwa M FaridSafaa S ElGamalAmira Sayed HanafyPublished in: Drug development and industrial pharmacy (2021)
CX-NP2 did not induce a statistically significant oxidative stress or neuroinflammation in rat brains after 30-day treatment, they rather elicited neuroprotective potentials.HighlightsIntranasal GH/chitosan complex nanoparticles (CX-NP2) show promising potential as a brain targeting carrier.Compared to GH nasal solution, nasal CX-NP2 formulation did not exert oxidative stress nor neuroinflammation when administered for 30 days.
Keyphrases
- oxidative stress
- cerebral ischemia
- drug delivery
- subarachnoid hemorrhage
- blood brain barrier
- brain injury
- diabetic rats
- dna damage
- cancer therapy
- ischemia reperfusion injury
- induced apoptosis
- growth hormone
- lipopolysaccharide induced
- traumatic brain injury
- chronic rhinosinusitis
- lps induced
- wound healing
- hyaluronic acid
- cognitive impairment
- inflammatory response
- heat shock
- smoking cessation