Penetration and pharmacokinetics of non-steroidal anti-inflammatory drugs in rat prostate tissue.

Venkata Kashyap YellepeddiJayashree RadhakrishnanRajan Radhakrishnan

Published in: The Prostate (2017)

This study for the first time reported the relative prostate tissue penetration of four NSAIDs. The pharmacokinetic data indicated that celecoxib has the highest penetration and retention in rat prostate tissues. Therefore, celecoxib may be considered as a better choice for the treatment CP/CPPS involving NSAIDs.

Keyphrases

anti inflammatory drugs
prostate cancer
benign prostatic hyperplasia
oxidative stress
gene expression
electronic health record
big data
decision making
smoking cessation